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ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9 published in ACS Chemical Neuroscience published in MDPI International Journal of Molecular Sciences

Our research paper titled ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9, authored by Shamasree Ghosh, Shanmugam Tamilselvi, Chloe Williams, Sanduni W. Jayaweera, Igor A. Iashchishyn, Darius Šulskis, Jonathan D. Gilthorpe, Anders Olofsson, Vytautas Smirnovas, Željko M. Svedružić, and Ludmilla A. Morozova-Roche (research group), has been published in special issue A Commemorative Issue in Honour of Rudolf Virchow: From Cell Morphology to Molecular Pathology-Volume 2 of MDPI open access journal International Journal of Molecular Sciences.

Professor Željko M. Svedružić passed away on 20 April 2023 and this article is dedicated to his memory.

Binding interactions of fatty acyl lipid mediators within the vanilloid pocket of TRPV1: A molecular dynamics study published in Elsevier Prostaglandins & Other Lipid Mediators

Our research paper titled Binding interactions of fatty acyl lipid mediators within the vanilloid pocket of TRPV1: A molecular dynamics study, authored by Nada Birkic, David Visentin, Željko Svedružić, and Christian A. Reynolds has been published in Volume 169 of Elsevier journal Prostaglandins & Other Lipid Mediators.

Highlights

  • TRPV1 can be activated by various endovanilloid lipid mediator ligands.
  • Molecular dynamic simulations reveal lipid mediator -TRPV1 binding interactions.
  • Lipid mediators with similar structures bind similarly within the vanilloid pocket.
  • Polar groups within the ligands’ acyl tails directly impact binding stability.

Posljednji intervju sa izv. prof. dr. sc. Željkom Svedružićem

In Memoriam prof. dr. sc. Željko Svedružić

Posljednji intervju sa izv. prof. dr. sc. ŽELJKOM SVEDRUŽIĆEM – Riječko superračunalo BURA i njegova primjena u znanosti

Željko Svedružić, izvanredni profesor Odjela za biotehnologiju Sveučilišta u Rijeci, iznenada nas je napustio 20. travnja 2023. godine. Njegov doprinos znanosti na Odjelu, kao i njegov utjecaj na studente, ostavit će neizbrisiv trag i veliku prazninu. Svojim entuzijazmom za znanosti, Željko Svedružić bio je inspiracija i motivacija mnogim studentima Odjela.

Pamtit ćemo ga kao profesora koji nas je upoznao sa metodama računalne kemije, profesora koji nam je ponudio djelić svoga znanja koje je stekao na brojnim, prestižnim svjetskim sveučilištima, ali prije svega, pamtit ćemo ga kao čovjeka koji nas je uvijek veselo pozdravljao na hodnicima Odjela, koji nam je uvijek bio spreman pomoći, koji nas je uvijek želio nešto novo naučiti i čija su vrata uvijek bila otvorena za sve nas. Njegova ostavština nastavit će živjeti kroz bezbrojne umove koje je dotaknuo i mnoga otkrića i napredak koji će njegovi studenti i kolege ostvariti u svojim karijerama.

Dragi profesore, Hvala Vam na svemu!

Vodila i montirala: Lana Žoldoš

Izvor: opis videa na YouTube kanalu studentske medijske platforme Kišobran

Podcast #03 SUPERRAČUNALO BURA gost: prof. dr. sc. Željko Svedružić | Kišobran UNIRI

Obituary: Dr Željko Svedružić

In English

Sourced from Department of Biotechnology:

Dr Željko Svedružić, associate professor at the Department of Biotechnology, University of Rijeka, passed away unexpectedly on the 20th April 2023.

We at the Department of Biotechnology knew him as a scientist, a colleague, a teacher and a mentor, and his passing has left a void in many of us. Underlying his apparently child-like naivety and occasionally provocative approach to his colleagues, were his strong ethical principles that guided him in both his work and private lives.

He was defined by his unique and quirky personality, his enthusiasm for science and his openness to everyone, because as he used to say jokingly: I am Svedružić (which loosely translates as "all friend") and I like to socialise with everyone. Now, though, there will be no more socialising, but our memories of the good and unique moments we spent with Željko will remain. He loved sports and was actively involved in them, and he was most proud of his butterfly swimming stroke. He left each of us who knew him with a series of anecdotes that we will remember and, one day, after we have accepted his departure, we will recount them with joy and fond memories.

Željko was born on 16th March 1969 in Osijek. He completed his graduate studies in Molecular Biology and Biochemistry at the Faculty of Science and Mathematics in Zagreb, and continued his doctoral studies at the Oklahoma State University, where he defended his doctorate in Enzymology and Enzyme Kinetics in 1998. He then undertook postdoctoral training at the University of Santa Barbara in California, Duke University in North Carolina, Washington State University in Washington, and the Catholic University of Leuven in Belgium.

After returning to Croatia in 2010, he was employed in the Medical Biochemistry laboratory of the Rab Psychiatric Hospital. Since summer 2013, he has been working as an Assistant Professor at the Department of Biotechnology, University of Rijeka, where he led several undergraduate and masters courses, acted as mentor to many successful research students, and was extremely active in the popularisation of science. In 2022 he was promoted to the status of Associate Professor. His research at the Department of Biotechnology focused on the structure, function and design of biomedically active molecules using in silico approaches.

Rest in peace, dear Željko.

Author: Rozi Andretić Waldowski

Na hrvatskom jeziku

Preuzeto s Odjela za biotehnologiju:

Izvanredni profesor Željko Svedružić, djelatnik Odjela za biotehnologiju Sveučilišta u Rijeci, nenadano nas je napustio 20. travnja 2023. godine.

Mi s Odjela za biotehnologiju znamo ga kao znanstvenika, kolegu, nastavnika i mentora koji svojim odlaskom ostavlja prazninu u mnogima od nas. Iza njegove naočigled djetinje naivnosti i ponekad provokativnog pristupa kolegama krili su se njegovi visoki osobni kriteriji kojima se rukovodio u poslovnom i privatnom životu.

Resila ga je osebujna ličnost, entuzijazam za znanošću, otvoreni pristup prema svima, jer kako je sam u šali znao reći: "Ja sam Svedružić i sa svima se volim družiti." Druženja više neće biti. Ostati će sjećanja na dobre i jedinstvene trenutke koje smo proveli s Željkom. Volio je sport i njime se aktivno bavio, a najponosniji bio je na svoj leptir stil plivanja. Svakome od nas tko ga je poznavao ostavio je u nasljeđe niz anegdota kojih ćemo se prisjećati i jednoga dana, kada njegov odlazak prihvatimo, sa smijehom prepričavati.

Željko je rođen 16. ožujka 1969. g. u Osijeku. Diplomski studij molekularne biologije i biokemije završava na Prirodoslovno-matematičkom fakultetu u Zagrebu, a doktorski studij nastavlja na Državnom Sveučilištu u Oklahomi gdje 1998. godine brani doktorat iz enzimologije i enzimske kinetike. Poslijedoktorska usavršavanja proveo je na Sveučilištu Santa Barbara u Kaliforniji, Sveučilištu Duke u Sjevernoj Karolini, Državnom Sveučilištu u Washingtonu u Washington-u i na Katoličkom Sveučilištu Leuven u Belgiji.

Nakon povratka u Republiku Hrvatsku 2010. godine zapošljava se u laboratoriju za medicinsku biokemiju u Psihijatrijskoj bolnici Rab. Od ljeta 2013. godine radi kao docent na Odjelu za biotehnologiju Sveučilišta u Rijeci gdje je nositelj nekoliko kolegija prijediplomskog i diplomskog studija, mentor uspješnih studenata diplomskog studija i vrlo aktivan popularizator znanosti. Od 2022. g. promoviran je u status izvanrednog profesora. Istraživački rad na Odjelu za biotehnologiju bio je usmjeren na strukturu, funkciju i dizajn biomedicinski aktivnih molekula korištenjem in silico pristupa.

Neka naš dragi Željko počiva u miru.

Autorica: Rozi Andretić Waldowski

The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer’s Disease in MDPI International Journal of Molecular Sciences

Our research paper titled The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer’s Disease, authored by Željko Svedružić, Vesna Šendula Jengić, and Lucija Ostojić, has been published in special issue Molecular and Supramolecular Systems: Design, Assembly, and Photonic Phenomena of MDPI open access journal International Journal of Molecular Sciences.

Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer’s disease published on bioRxiv

Our research preprint titled Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer’s disease, authored by Željko Svedružić, Vesna Šendula Jengić, and Lucija Ostojić, has been uploaded to bioRxiv.

Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein published in Nature Scientific Reports

Our research paper titled Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein, authored by Maciej Gielnik, Michał Taube, Lilia Zhukova, Igor Zhukov, Sebastian K. T. S. Wärmländer, Željko M. Svedružić, Wojciech M. Kwiatek, Astrid Gräslund, and Maciej Kozak, has been published in Volume 11 of Nature journal Scientific Reports.

Co-Aggregation of S100A9 with DOPA and Cyclen-Based Compounds Manifested in Amyloid Fibril Thickening without Altering Rates of Self-Assembly published in MDPI International Journal of Molecular Sciences

Our research paper titled Co-Aggregation of S100A9 with DOPA and Cyclen-Based Compounds Manifested in Amyloid Fibril Thickening without Altering Rates of Self-Assembly, authored by Lili Arabuli, Igor A. Iashchishyn, Nina V. Romanova, Greta Musteikyte, Vytautas Smirnovas, Himanshu Chaudhary, Željko M. Svedružić, and Ludmilla A. Morozova-Roche has been published in Volume 22 Issue 16 of MDPI International Journal of Molecular Sciences.

Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases published in ACS Applied Materials & Interfaces

Our research paper titled Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases, authored by Himanshu Chaudhary, Igor A. Iashchishyn, Nina V. Romanova, Mark A. Rambaran, Greta Musteikyte, Vytautas Smirnovas, Michael Holmboe, C. André Ohlin, Željko M. Svedružić, and Ludmilla A. Morozova-Roche (research group), has been published in Volume 13, Issue 23 of ACS journal Applied Materials & Interfaces.

Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer's Disease published in ACS Chemical Neuroscience

Our research paper titled Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer's Disease, authored by Manuela Leri, Himanshu Chaudhary, Igor A. Iashchishyn, Jonathan Pansieri, Željko M. Svedružić, Silvia Gómez Alcalde, Greta Musteikyte, Vytautas Smirnovas, Massimo Stefani, Monica Bucciantini, and Ludmilla A. Morozova-Roche (research group), has been published in Volume 12, Issue 11 of ACS journal Chemical Neuroscience.